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The concomitant use of METHADOSE with all cytochrome P450 3A4, 2B6, 2C19, 2C9 or 2D6 inhibitors may possibly bring about an increase in methadone plasma concentrations, which could result in potentially fatal respiratory depression. Furthermore, discontinuation of concomitantly employed cytochrome P450 3A4, 2B6, 2C19, or 2C9 inducers could also res